منابع مشابه
Anaphylaxis in the Isolated Heart
The isolated hearts of guinea pigs sensitized to horse serum have been shown to react characteristically upon exposure to small amounts of antigen. The cardiac rate is temporarily accelerated and transient alterations in amplitude of contraction are to be observed. Electrocardiographic abnormalities, previously recorded by remote leads during anaphylactic shock in the intact animal, have been r...
متن کاملThe Effects of Anaphylaxis, and of Histamine, upon the Coronary Arteries in the Isolated Heart
Anaphylaxis in the isolated, perfused hearts of cats has been shown to be accompanied by a considerable, though transient, increase in coronary flow. This result is contrasted with that observed in the hearts of guinea pigs and rabbits in which the coronary arteries are constricted during anaphylaxis. Attention is directed to the fact that, in the hearts of these three species, the effects of a...
متن کاملHistamine release and intracellular potentials during anaphylaxis in the isolated heart.
ALTHOUGH cardiovascular collapse has been recognized as a concomitant of gross anaphylaxis in many species of animal, it lias been the general opinion that the circulatory irregularities associated with fatal anaphylactic shock are secondary manifestations, usually resulting from the asphyxia caused by bronchospasm. While this view, first proposed by Auer and Lewis in 1910, is perfectly plausib...
متن کاملQuantitative adsorption of antibody by the isolated heart and the intensity of cardiac anaphylaxis.
IN A RECENT publication from this laboratory, it was shown that the events succeeding the administration of antigen to a perfused heart taken from an ovalbuminsensitive animal include an increase in the rate and amplitude of contraction, a decrease in coronary flow, heart block, and the release of a physiologically active material having the pharmacological and chemical properties of histamine....
متن کاملGlucagon Effects on 3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis
We estimated the influence of acute glucagon applications on (3)H-histamine uptake by the isolated guinea-pig heart, during a single (3)H-histamine passage through the coronary circulation, before and during anaphylaxis, and the influence of glucagon on level of histamine, NO, O2 (-), and H2O2 in the venous effluent during anaphylaxis. Before anaphylaxis, glucagon pretreatment does not change (...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1938
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.67.2.169